Provocation testing is irreplaceable to uncover or refute Brugada syndrome – an electrocardiographic validation study during ajmaline provocation

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Feasibility and outcomes of ajmaline provocation testing for Brugada syndrome in children in a specialist paediatric inherited cardiovascular diseases centre

OBJECTIVES Brugada syndrome (BrS) is an inherited arrhythmia syndrome that causes sudden cardiac death in the young. The class Ia antiarrhythmic ajmaline can be used to provoke the diagnostic ECG pattern. Its use has been established in adults, but little data exist on the ajmaline provocation test in children. This study aims to determine the safety and feasibility of ajmaline provocation test...

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Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome

Introduction Sodium channel blockade (SCB) with a class Ia or Ic antiarrhythmic agent (eg, ajmaline or procainamide, respectively) is used in the unmasking and diagnosis of Brugada syndrome (BrS). SCB is performed frequently as part of family screening or in symptomatic patients with a suggestive electrocardiogram (ECG), and concurrent medications known to potentiate arrhythmias or contraindica...

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Usefulness of patient's history and non-invasive electrocardiographic parameters in prediction of ajmaline test results in patients with suspected Brugada syndrome

INTRODUCTION The aim of the work was to assess the usefulness of patient's history and non-invasive electrocardiographic parameters in the prediction of ajmaline test results in patients with suspected Brugada syndrome. MATERIAL AND METHODS The study involved a group of 59 patients (37 men) at average age of 31.6 ±12.2 years with suspected concealed form of Brugada syndrome. Pharmacological p...

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BRUGADA diagnosis not to be missed Brugada syndrome : an electrocardiographic

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Testing bronchial hyper-responsiveness: provocation or peak expiratory flow variability?

BACKGROUND Assessing bronchial hyper-responsiveness (BHR) is a main diagnostic criterion of asthma. Provocation testing is not readily available in general practice, but peak expiratory flow (PEF) is. Several guidelines promote the use of PEF variability as a diagnostic tool for BHR. This study tested the agreement between histamine challenge testing and PEF variability, and the consequences fo...

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ژورنال

عنوان ژورنال: European Heart Journal

سال: 2020

ISSN: 0195-668X,1522-9645

DOI: 10.1093/ehjci/ehaa946.0372